Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

2. Molecular Representations

How To Determine Solubility

Organic Chemistry

2. Molecular Representations

How To Determine Solubility

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Multiple Choice

Which of the following factors is most important in determining the solubility of a compound in water?

Molecular weight of the compound

Polarity of the compound

Color of the compound

Melting point of the compound

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Verified step by step guidance

Understand that solubility in water is primarily determined by the ability of a compound to interact with water molecules. Water is a polar solvent, meaning it has a partial positive charge on one side and a partial negative charge on the other.

Recognize that polar compounds tend to dissolve well in polar solvents like water due to the 'like dissolves like' principle. This means that compounds with polar bonds or ionic charges can interact favorably with water molecules.

Consider the role of hydrogen bonding. Compounds that can form hydrogen bonds with water are generally more soluble. This is because hydrogen bonds are strong dipole-dipole attractions that significantly enhance solubility.

Evaluate the molecular structure of the compound. Look for functional groups that are polar or capable of hydrogen bonding, such as hydroxyl (-OH), carboxyl (-COOH), or amino (-NH2) groups.

Conclude that while molecular weight, color, and melting point can influence physical properties, the polarity of the compound is the most critical factor in determining its solubility in water.