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Multiple Choice
Which drug should be available to counteract the effect of edrophonium chloride?
A
Physostigmine
B
Atropine
C
Pyridostigmine
D
Neostigmine
Verified step by step guidance
1
Understand the role of edrophonium chloride: It is a reversible acetylcholinesterase inhibitor, which increases the level of acetylcholine at the neuromuscular junction.
Recognize the symptoms of edrophonium chloride overdose: Excess acetylcholine can lead to symptoms such as muscle cramps, increased salivation, and bradycardia.
Identify the mechanism of action of atropine: Atropine is a muscarinic antagonist that blocks the action of acetylcholine at muscarinic receptors, thereby counteracting the effects of excess acetylcholine.
Consider the pharmacological action of other options: Physostigmine, pyridostigmine, and neostigmine are also acetylcholinesterase inhibitors, which would exacerbate the effects of edrophonium chloride rather than counteract them.
Conclude that atropine is the appropriate drug to counteract the effects of edrophonium chloride due to its ability to block muscarinic receptors and reduce the symptoms of cholinergic excess.