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Multiple Choice
Which mechanism do many diuretics use to increase urine volume in the body?
A
Stimulation of antidiuretic hormone release
B
Inhibition of carbonic anhydrase
C
Activation of aldosterone receptors
D
Enhancement of sodium reabsorption
Verified step by step guidance
1
Understand the role of diuretics: Diuretics are substances that promote the production of urine, helping to remove excess fluid from the body.
Identify the mechanisms listed: The problem provides several mechanisms, including stimulation of antidiuretic hormone release, inhibition of carbonic anhydrase, activation of aldosterone receptors, and enhancement of sodium reabsorption.
Analyze the function of carbonic anhydrase: Carbonic anhydrase is an enzyme that helps convert carbon dioxide and water into carbonic acid, which then dissociates into bicarbonate and hydrogen ions. Inhibition of this enzyme affects the reabsorption of bicarbonate in the kidneys, leading to increased urine production.
Consider the effects of inhibiting carbonic anhydrase: By inhibiting carbonic anhydrase, diuretics reduce the reabsorption of bicarbonate, sodium, and water in the proximal tubule of the nephron, leading to increased urine volume.
Conclude the mechanism: The inhibition of carbonic anhydrase is a common mechanism used by many diuretics to increase urine volume, as it directly affects the reabsorption processes in the kidneys.