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Multiple Choice
Which of the following does not accurately apply to the Ames test?
A
It directly measures the carcinogenic potential of a compound.
B
It is used to assess the mutagenic potential of chemical compounds.
C
It requires the use of mammalian liver enzymes to simulate metabolism.
D
It involves the use of bacteria to detect chemical mutagens.
Verified step by step guidance
1
Understand the purpose of the Ames test: The Ames test is designed to assess the mutagenic potential of chemical compounds, not directly their carcinogenic potential.
Recognize the role of bacteria in the Ames test: The test uses strains of bacteria, typically Salmonella typhimurium, to detect mutations caused by chemical compounds.
Consider the use of mammalian liver enzymes: The test often incorporates mammalian liver enzymes to simulate the metabolic processes that occur in humans, which can convert non-mutagenic compounds into mutagenic ones.
Differentiate between mutagenicity and carcinogenicity: Mutagenicity refers to the ability of a substance to cause genetic mutations, while carcinogenicity refers to the ability to cause cancer. The Ames test focuses on mutagenicity.
Identify the statement that does not apply: The statement 'It directly measures the carcinogenic potential of a compound' does not accurately describe the Ames test, as it assesses mutagenic potential, not carcinogenic potential.