Multiple Choice
How many turns of the citric acid cycle are required to completely oxidize one molecule of glucose?
33. The Organic Chemistry of Metabolic Pathways
Intro to Citric Acid Cycle
Struggling with Organic Chemistry?
Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
Which enzyme catalyzes the conversion of citrate to isocitrate in the citric acid cycle?
A
Aconitase
B
Citrate synthase
C
Isocitrate dehydrogenase
D
Succinate dehydrogenase
Verified step by step guidance1
Begin by understanding the citric acid cycle, also known as the Krebs cycle, which is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide.
Identify the specific step in the citric acid cycle where citrate is converted to isocitrate. This is an important transformation that involves the rearrangement of atoms within the citrate molecule.
Recognize that the enzyme responsible for this conversion is aconitase. Aconitase catalyzes the reversible isomerization of citrate to isocitrate via the intermediate cis-aconitate.
Understand the role of aconitase in the cycle: it facilitates the dehydration of citrate to form cis-aconitate, followed by the hydration of cis-aconitate to form isocitrate.
Differentiate aconitase from other enzymes listed: Citrate synthase catalyzes the formation of citrate from oxaloacetate and acetyl-CoA, Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate, and Succinate dehydrogenase catalyzes the oxidation of succinate to fumarate.
2:21mWatch next
Master Intro to Citric Acid Cycle Concept 1 with a bite sized video explanation from Johnny
Start learningRelated Videos
Related Practice
Intro to Citric Acid Cycle practice set
Problem sets built by lead tutorsExpert video explanations