Determine the product in the following conjugated addition reaction.

The following covalent inhibitor blocks function in a protease found in the porcine epidemic diarrhea virus by reacting with a cysteine amino acid residue (shown below) in the active site. Draw the expected complex that forms between the inhibitor and the enzyme active site (J. Med. Chem. 2017, 60, 3212–3216.) [Assume the presence of active site bases if you need them.]

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Show how the following products might be synthesized from suitable Michael donors and acceptors.

(e)

In Solved Problem 22-9, the target molecule was synthesized using a Michael addition to form the bond that is β,γ to the upper carbonyl group. Another approach is to use a Michael addition to form the bond that is β,γ to the other (lower) carbonyl group. Show how you would accomplish this alternative synthesis.

Show how cyclohexanone might be converted to the following δ-diketone (Hint: Stork).

Determine the product in the following conjugated addition reaction.

Determine the product in the following conjugated addition reaction

What reagents should be used to prepare the following compounds?

b.