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Multiple Choice
Which type of mutation is commonly involved in the conversion of proto-oncogenes to oncogenes?
A
Silent mutation
B
Deletion mutation
C
Frameshift mutation
D
Point mutation
Verified step by step guidance
1
Understand the role of proto-oncogenes: Proto-oncogenes are normal genes that, when mutated, can become oncogenes and contribute to cancer development by promoting cell growth and division.
Identify the types of mutations: Mutations can be classified into several types, including silent mutations, deletion mutations, frameshift mutations, and point mutations.
Define point mutations: A point mutation is a change in a single nucleotide base pair in DNA. This can lead to a change in the protein product, potentially altering its function.
Consider the impact of point mutations on proto-oncogenes: Point mutations can lead to a gain-of-function in proto-oncogenes, converting them into oncogenes by causing the protein to be overactive or expressed at higher levels.
Conclude why point mutations are commonly involved: Due to their ability to alter protein function or expression, point mutations are a common mechanism by which proto-oncogenes are converted into oncogenes, contributing to cancer development.