Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

2. Molecular Representations

Functional Groups

Organic Chemistry

2. Molecular Representations

Functional Groups

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Multiple Choice

Which of the following functional groups is commonly found as the active site in enzymes?

Hydroxyl group

Amine group

Thiol group

Carboxyl group

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Verified step by step guidance

Understand the role of functional groups in enzyme active sites. Enzymes are proteins that catalyze biochemical reactions, and their active sites are often composed of specific functional groups that interact with substrates.

Recognize that the thiol group, represented as

R - S H

, is a common functional group in enzyme active sites. Thiol groups contain sulfur and are known for their ability to form disulfide bonds, which can be crucial for enzyme activity.

Consider the chemical properties of thiol groups. They are nucleophilic and can participate in redox reactions, making them versatile in catalysis and important in maintaining the structure and function of enzymes.

Compare the thiol group with other functional groups listed: hydroxyl (

R - OH

), amine (

R - NH

₂), and carboxyl (

R - COOH

). While these groups are also important in biochemistry, thiol groups are particularly noted for their role in enzyme active sites.

Reflect on examples of enzymes with thiol groups in their active sites, such as cysteine proteases, which utilize the thiol group of cysteine residues to perform catalytic functions.