Textbook Question
Identify the following solvents as polar protic, polar aprotic, or nonpolar.
(e)
8. Elimination Reactions
Solvents
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Which of the following is the best base to use in an E2 reaction?
A
H2O
B
C
D
Verified step by step guidance1
Understand the E2 reaction mechanism: E2 reactions are bimolecular elimination reactions where a base removes a proton from a substrate, leading to the formation of a double bond.
Identify the characteristics of a good base for E2 reactions: A strong base is typically required to effectively abstract a proton from the substrate, facilitating the elimination process.
Analyze the provided bases: The images show different chemical structures that can act as bases. Evaluate their strength and steric hindrance.
Consider the steric hindrance: Bulky bases are often preferred in E2 reactions because they can effectively abstract protons without causing substitution reactions.
Evaluate the base strength: Compare the basicity of the given compounds. Lithium diisopropylamide (LDA) is a strong, non-nucleophilic base, making it suitable for E2 reactions.
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