Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

27. Heterocycles

SNAr Reactions of Pyridine

Organic Chemistry

27. Heterocycles

SNAr Reactions of Pyridine

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Multiple Choice

Determine the final product for the following reaction.

final product

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Verified step by step guidance

Identify the starting material and the reagent: The starting material is a pyridine derivative with a nitro group (NO2) and a methyl group attached to the aromatic ring. The reagent is ethylmagnesium bromide (EtMgBr), a Grignard reagent.

Understand the role of the Grignard reagent: Grignard reagents are strong nucleophiles and bases. They typically add to electrophilic centers such as carbonyl groups. However, in this case, there is no carbonyl group present, so consider other possible reactions.

Consider the reactivity of the nitro group: The nitro group is a strong electron-withdrawing group, which can influence the reactivity of the aromatic ring. It can make the ring more susceptible to nucleophilic aromatic substitution (NAS) reactions.

Analyze the possible sites for reaction: The Grignard reagent can potentially attack the aromatic ring at a position ortho or para to the nitro group, due to the electron-withdrawing nature of the nitro group making these positions more electrophilic.

Predict the final product: The Grignard reagent will likely add to the position ortho to the nitro group, resulting in the formation of a new carbon-carbon bond. This will lead to the formation of a new alkylated pyridine derivative as the final product.