Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

22. Carboxylic Acid Derivatives: NAS

Nucleophilic Acyl Substitution

Organic Chemistry

22. Carboxylic Acid Derivatives: NAS

Nucleophilic Acyl Substitution

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1:37 minutes

Problem 37d

Textbook Question

Predict the products and propose mechanisms for the following reactions.
(d)

Verified step by step guidance

Analyze the given reaction: Identify the type of reaction (e.g., substitution, elimination, addition, etc.) based on the reactants, reagents, and conditions provided. Look for functional groups and any specific reagents that indicate the reaction pathway.

Predict the products: Based on the reaction type, determine the possible products. For example, if the reaction involves a nucleophilic substitution, consider whether it follows an SN1 or SN2 mechanism. If it involves elimination, determine whether it is E1 or E2.

Propose the mechanism: Break down the reaction into individual steps. For example, if it is an SN1 reaction, describe the formation of the carbocation intermediate and the subsequent attack by the nucleophile. Use curved arrows to show the movement of electrons.

Consider stereochemistry: If the reaction involves chiral centers or stereochemical outcomes, analyze whether the product will be racemic, retain configuration, or invert configuration. This depends on the mechanism (e.g., SN2 leads to inversion of configuration).

Verify the reaction conditions: Ensure that the proposed mechanism and products are consistent with the reagents and conditions provided in the problem. For example, strong bases favor elimination (E2), while polar protic solvents favor SN1 reactions.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Reaction Mechanisms

Reaction mechanisms describe the step-by-step process by which reactants transform into products. Understanding these mechanisms involves identifying the intermediates, transition states, and the sequence of bond-breaking and bond-forming events. This knowledge is crucial for predicting the products of a reaction and understanding the underlying chemistry.

Types of Organic Reactions

Organic reactions can be classified into several types, including substitution, addition, elimination, and rearrangement reactions. Each type has distinct characteristics and mechanisms. Recognizing the type of reaction occurring helps in predicting the products and understanding the conditions under which the reaction takes place.

Functional Groups

Functional groups are specific groups of atoms within molecules that are responsible for the characteristic chemical reactions of those molecules. Identifying functional groups in reactants is essential for predicting the products of a reaction, as they dictate reactivity and the types of transformations that can occur during the reaction.

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