Table of contents

Skip topic navigation

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

34. Nucleic Acids

DNA Double Helix

Organic Chemistry

34. Nucleic Acids

DNA Double Helix

Previous problemNext problem

Struggling with Organic Chemistry?

Join thousands of students who trust us to help them ace their exams!Watch the first video

Multiple Choice

Clinical trials include the use of DNA-binding drugs that facilitate the breaking of double-stranded DNA in their function. A hypothetical drug used in the treatment of leukemia requires interaction with the grooves of DNA. If the minor groove is A–T rich and the major groove is G–C rich, which of the following statements can be true?

The drug would more readily bind to the minor groove of DNA.

The drug would more readily bind to the major groove of DNA.

The drug would equally bind to the minor and major grooves of DNA.

Not enough information is given.

Previous problemNext problem

Verified step by step guidance

Understand the structure of DNA: DNA is a double helix with two grooves, the major and minor grooves, which are formed due to the asymmetrical attachment of the base pairs.

Identify the base pair composition of the grooves: The minor groove is A–T rich, while the major groove is G–C rich.

Consider the drug's binding preference: Drugs that bind to DNA often have specific preferences for A–T or G–C rich regions due to the hydrogen bonding patterns and the shape of the grooves.

Analyze the binding affinity: A–T rich regions in the minor groove may provide a more favorable binding site for certain drugs due to the specific hydrogen bonding and spatial configuration.

Evaluate the given statements: Based on the drug's interaction with A–T or G–C rich regions, determine which statement about the drug's binding preference is most likely true.