Multiple Choice
What are two possible metabolic pathways for acetyl-CoA once it has been produced in the cell?
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Intro to Organic Chemistry
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Which codon in the DNA sequence is altered in sickle cell anemia?
A
GAG to GTG
B
GGA to GCA
C
GTA to GTT
D
GAA to GAC
Verified step by step guidance1
Understand the genetic basis of sickle cell anemia: It is caused by a mutation in the hemoglobin gene, specifically in the beta-globin chain.
Identify the normal DNA sequence for the beta-globin gene: The normal sequence codes for the amino acid glutamic acid (Glu) using the codon GAG.
Recognize the mutation: In sickle cell anemia, the codon GAG is altered to GTG, which codes for the amino acid valine (Val) instead of glutamic acid.
Compare the options provided: Look for the option where the codon GAG is changed to GTG, as this is the specific mutation responsible for sickle cell anemia.
Confirm the correct answer: The correct alteration is GAG to GTG, which is the mutation that leads to the production of sickle hemoglobin.
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