Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

29. Amino Acids

Proteins and Amino Acids

Organic Chemistry

29. Amino Acids

Proteins and Amino Acids

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Multiple Choice

Which missense mutation is least likely to affect protein function?

Substitution of phenylalanine with serine

Substitution of glycine with proline

Substitution of arginine with glutamic acid

Substitution of leucine with isoleucine

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Verified step by step guidance

Understand the concept of a missense mutation: A missense mutation is a point mutation in which a single nucleotide change results in a codon that codes for a different amino acid. This can affect protein function depending on the properties of the amino acids involved.

Consider the properties of the amino acids involved in each substitution: Amino acids have different properties such as size, charge, and hydrophobicity, which can affect protein structure and function.

Analyze the substitution of phenylalanine with serine: Phenylalanine is a nonpolar, aromatic amino acid, while serine is polar and uncharged. This change could significantly affect protein function due to differences in polarity and size.

Examine the substitution of glycine with proline: Glycine is small and flexible, while proline is rigid and can introduce kinks in protein structure. This substitution is likely to have a significant impact on protein function.

Evaluate the substitution of leucine with isoleucine: Both leucine and isoleucine are nonpolar, aliphatic amino acids with similar sizes and properties. This substitution is least likely to affect protein function due to the similarity between the two amino acids.