Table of contents

1. A Review of General Chemistry5h 5m
2. Molecular Representations1h 14m
3. Acids and Bases2h 46m
4. Alkanes and Cycloalkanes4h 17m
5. Chirality3h 39m
6. Thermodynamics and Kinetics1h 22m
7. Substitution Reactions1h 48m
8. Elimination Reactions2h 30m
9. Alkenes and Alkynes2h 9m
10. Addition Reactions3h 19m
11. Radical Reactions1h 58m
12. Alcohols, Ethers, Epoxides and Thiols2h 42m
13. Alcohols and Carbonyl Compounds2h 17m
14. Synthetic Techniques1h 26m
15. Analytical Techniques:IR, NMR, Mass Spect7h 3m
16. Conjugated Systems6h 13m
17. Ultraviolet Spectroscopy51m
18. Aromaticity2h 34m
19. Reactions of Aromatics: EAS and Beyond5h 1m
20. Phenols55m
21. Aldehydes and Ketones: Nucleophilic Addition4h 56m
22. Carboxylic Acid Derivatives: NAS2h 51m
23. The Chemistry of Thioesters, Phophate Ester and Phosphate Anhydrides1h 10m
24. Enolate Chemistry: Reactions at the Alpha-Carbon1h 53m
25. Condensation Chemistry2h 9m
26. Amines1h 43m
27. Heterocycles2h 0m
28. Carbohydrates5h 53m
29. Amino Acids4h 20m
30. Peptides and Proteins2h 42m
31. Catalysis in Organic Reactions1h 30m
32. Lipids 2h 50m
33. The Organic Chemistry of Metabolic Pathways2h 52m
34. Nucleic Acids1h 32m
35. Transition Metals6h 14m
36. Synthetic Polymers1h 49m

34. Nucleic Acids

Hydrolysis of Nucleosides

Organic Chemistry

34. Nucleic Acids

Hydrolysis of Nucleosides

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Multiple Choice

Which component of an RNA nucleotide makes it more prone to hydrolysis than DNA?

The presence of a 2'-hydroxyl group on the ribose sugar

The absence of a 3'-hydroxyl group

The presence of uracil instead of thymine

The phosphodiester bond

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Verified step by step guidance

Understand the structure of RNA and DNA nucleotides. Both consist of a sugar, a phosphate group, and a nitrogenous base. RNA contains ribose sugar, while DNA contains deoxyribose sugar.

Identify the key structural difference between ribose and deoxyribose. Ribose has a hydroxyl group (-OH) at the 2' position, whereas deoxyribose lacks this group, having only a hydrogen atom at the 2' position.

Consider the chemical reactivity of the 2'-hydroxyl group in RNA. This group can act as a nucleophile, making RNA more susceptible to hydrolysis, especially under alkaline conditions.

Evaluate the role of the 2'-hydroxyl group in the stability of RNA compared to DNA. The presence of this group in RNA leads to increased hydrolysis, which is not the case for DNA due to the absence of the 2'-hydroxyl group.

Conclude that the presence of the 2'-hydroxyl group on the ribose sugar in RNA is the component that makes RNA more prone to hydrolysis than DNA.