Table of contents

1. Matter and Measurements4h 31m
2. Atoms and the Periodic Table5h 23m
3. Ionic Compounds2h 18m
4. Molecular Compounds2h 18m
5. Classification & Balancing of Chemical Reactions3h 17m
6. Chemical Reactions & Quantities2h 27m
7. Energy, Rate and Equilibrium3h 46m
8. Gases, Liquids and Solids3h 25m
9. Solutions4h 10m
10. Acids and Bases3h 29m
11. Nuclear Chemistry56m
BONUS: Lab Techniques and Procedures1h 38m
BONUS: Mathematical Operations and Functions47m
12. Introduction to Organic Chemistry1h 34m
13. Alkenes, Alkynes, and Aromatic Compounds2h 12m
14. Compounds with Oxygen or Sulfur1h 6m
15. Aldehydes and Ketones1h 1m
16. Carboxylic Acids and Their Derivatives1h 11m
17. Amines39m
18. Amino Acids and Proteins1h 51m
19. Enzymes1h 37m
20. Carbohydrates1h 41m
21. The Generation of Biochemical Energy2h 8m
22. Carbohydrate Metabolism2h 22m
23. Lipids2h 26m
24. Lipid Metabolism1h 45m
25. Protein and Amino Acid Metabolism1h 37m
26. Nucleic Acids and Protein Synthesis2h 54m

16. Carboxylic Acids and Their Derivatives

Amide Hydrolysis

GOB Chemistry

16. Carboxylic Acids and Their Derivatives

Amide Hydrolysis

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Multiple Choice

Determine the carboxylate anion formed in the following reaction between the given amide and aqueous base.

chemical structure

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Verified step by step guidance

Identify the functional group in the given amide. The structure shows an amide group, which consists of a carbonyl group (C=O) directly bonded to a nitrogen atom (N).

Recognize the reaction conditions: the presence of an aqueous base (OH-) and heat. This suggests a hydrolysis reaction, specifically base-catalyzed hydrolysis of the amide.

Understand the mechanism: In base-catalyzed hydrolysis, the hydroxide ion (OH-) attacks the carbonyl carbon of the amide, leading to the formation of a tetrahedral intermediate.

The intermediate collapses, expelling the amine group and forming a carboxylic acid. Under basic conditions, the carboxylic acid deprotonates to form a carboxylate anion.

Examine the structure of the starting amide to determine the resulting carboxylate anion. The carbonyl carbon of the amide becomes the carbonyl carbon of the carboxylate anion, and the rest of the structure remains unchanged except for the conversion of the amide nitrogen to a leaving group.