Multiple Choice
Which one of the following coenzymes is not a part of the β-oxidation pathway?
24. Lipid Metabolism
Oxidation of Fatty Acids
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How many total FADH2, NADH, and acetyl CoA molecules will be produced when stearic acid undergoes β‑oxidation?
A
10 FADH2, 10 NADH, and 9 acetyl CoA
B
9 FADH2, 9 NADH, and 9 acetyl CoA
C
8 FADH2, 8 NADH, and 8 acetyl CoA
D
8 FADH2, 8 NADH, and 9 acetyl CoA
Verified step by step guidance1
Understand the process of β-oxidation: It is the catabolic process by which fatty acid molecules are broken down in the mitochondria to generate acetyl-CoA, NADH, and FADH2.
Identify the structure of stearic acid: Stearic acid is a saturated fatty acid with 18 carbon atoms.
Determine the number of cycles of β-oxidation: Each cycle of β-oxidation shortens the fatty acid chain by 2 carbon atoms and produces 1 FADH2, 1 NADH, and 1 acetyl-CoA. For stearic acid (18 carbons), 8 cycles are needed to fully oxidize the fatty acid.
Calculate the number of FADH2 and NADH molecules: Since each cycle produces 1 FADH2 and 1 NADH, 8 cycles will produce 8 FADH2 and 8 NADH molecules.
Calculate the number of acetyl-CoA molecules: Each cycle produces 1 acetyl-CoA, and the final 2-carbon fragment also forms an acetyl-CoA, resulting in a total of 9 acetyl-CoA molecules.
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