Multiple Choice
Which amino acid provides the NH4+ for the formation of carbamoyl phosphate?
25. Protein and Amino Acid Metabolism
The Urea Cycle
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Which of the following metabolites is hydrolyzed in the urea cycle to produce ornithine and urea?
A
Citrulline
B
Arginine
C
Aspartate
D
Argininosuccinate
Verified step by step guidance1
Understand the urea cycle: The urea cycle is a series of biochemical reactions that produce urea ((NH2)2CO) from ammonia (NH3). It is a crucial process for removing excess nitrogen from the body.
Identify the role of arginine: In the urea cycle, arginine is hydrolyzed by the enzyme arginase to produce ornithine and urea. This is the final step of the urea cycle.
Recognize the reaction: The hydrolysis of arginine involves the addition of a water molecule, breaking the bond in arginine to form ornithine and urea.
Differentiate between metabolites: Citrulline, aspartate, and argininosuccinate are also part of the urea cycle, but they do not undergo hydrolysis to produce ornithine and urea. Citrulline and aspartate are involved in earlier steps, while argininosuccinate is a precursor to arginine.
Conclude with the correct metabolite: Based on the urea cycle's steps, arginine is the metabolite that is hydrolyzed to produce ornithine and urea.
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