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Multiple Choice
D-ribose is an aldopentose sugar that is found in the DNA. It commonly exists as a five-membered β anomer. Draw D‑ribose in its cyclic hemiacetal form.
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1
Identify the structure of D-ribose in its linear form. D-ribose is an aldopentose, which means it has five carbon atoms and an aldehyde group. The linear structure shows the aldehyde group at the top and hydroxyl groups on the other carbons.
Understand the concept of hemiacetal formation. A hemiacetal is formed when an alcohol group reacts with an aldehyde group within the same molecule, leading to a cyclic structure.
Recognize that D-ribose commonly forms a five-membered ring, known as a furanose form. This involves the reaction between the aldehyde group at C1 and the hydroxyl group at C4.
Determine the orientation of the hydroxyl groups in the cyclic form. In the β-anomer, the hydroxyl group on the anomeric carbon (C1) is on the same side as the CH2OH group at C5.
Draw the cyclic structure of D-ribose in its β-anomer form. Ensure that the ring is a five-membered furanose, with the oxygen atom in the ring and the correct orientation of the hydroxyl groups as per the β-anomer configuration.