Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Sequential (KNF) Model

Biochemistry

7. Enzyme Inhibition and Regulation

Sequential (KNF) Model

Previous problemNext problem

Struggling with Biochemistry?

Join thousands of students who trust us to help them ace their exams!Watch the first video

Multiple Choice

True or False: Most allosteric enzymes behave according to the concerted model, not the sequential model.

True.

False.

Previous problemNext problem

Verified step by step guidance

Understand the two models of allosteric enzyme behavior: the concerted model (also known as the Monod-Wyman-Changeux model) and the sequential model (also known as the Koshland-Némethy-Filmer model).

In the concerted model, all subunits of an enzyme are either in the tense (T) state or the relaxed (R) state. Binding of a substrate to one subunit causes a shift in all subunits to the R state simultaneously.

In the sequential model, subunits can change from the T state to the R state independently. Binding of a substrate to one subunit increases the likelihood of neighboring subunits transitioning to the R state, but does not require all subunits to change simultaneously.

Most allosteric enzymes do not strictly adhere to one model over the other. They often exhibit characteristics of both models, with some enzymes showing more concerted behavior and others more sequential behavior.

Therefore, the statement that most allosteric enzymes behave according to the concerted model, not the sequential model, is false. Both models are used to describe different aspects of enzyme behavior, and many enzymes exhibit a combination of both models.