Multiple Choice
The Sequential model for allosteric enzyme behavior:
7. Enzyme Inhibition and Regulation
Sequential (KNF) Model
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Which of the following best describes negative cooperativity?
A
Binding of one substrate molecule stimulates binding of a second substrate.
B
Binding of one substrate molecule inhibits binding of a second substrate.
C
Binding of one substrate molecule leads to negative reaction rates.
D
Binding of one substrate molecule causes a negative effect/result in the cell.
Verified step by step guidance1
Understand the concept of cooperativity: Cooperativity refers to the interaction process by which binding of a molecule to a target site affects the binding of additional molecules to the same target.
Differentiate between positive and negative cooperativity: In positive cooperativity, the binding of one substrate molecule increases the affinity of the target for additional substrate molecules. In negative cooperativity, the opposite occurs.
Focus on negative cooperativity: Negative cooperativity means that the binding of one substrate molecule decreases the affinity of the target for subsequent substrate molecules.
Analyze the given options: The correct description of negative cooperativity is the one where the binding of one substrate molecule inhibits the binding of a second substrate molecule.
Select the correct answer: Based on the understanding of negative cooperativity, choose the option that states 'Binding of one substrate molecule inhibits binding of a second substrate.'
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