Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

12. Biosignaling

Jak-Stat Signaling

Biochemistry

12. Biosignaling

Jak-Stat Signaling

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Multiple Choice

When the JAK-STAT signaling cascade is activated, which of the following occurs?

Adenylate cyclase produces cAMP.

Ras GTPase activity is activated.

Activated STAT5 is translocated to the nucleus.

Grb2 binds Sos.

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Verified step by step guidance

Understand the JAK-STAT signaling pathway: The JAK-STAT pathway is a chain of interactions between proteins in a cell, and it is one of the ways cells respond to extracellular signals. It involves Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs).

Identify the key components: JAKs are tyrosine kinases that, when activated by cytokines, phosphorylate STAT proteins. Phosphorylated STATs dimerize and translocate to the nucleus to act as transcription factors.

Recognize the role of STAT5: In the context of the JAK-STAT pathway, STAT5 is one of the STAT proteins that, upon activation and phosphorylation, forms dimers and moves into the nucleus to influence gene expression.

Differentiate from other pathways: The options provided include components from other signaling pathways. Adenylate cyclase and cAMP are part of the G-protein coupled receptor pathway, Ras GTPase is involved in the MAPK/ERK pathway, and Grb2 binding to Sos is part of the Ras signaling pathway.

Conclude with the correct process: In the JAK-STAT pathway, the activation of STAT5 leads to its translocation to the nucleus, which is the correct answer among the options provided.