Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

12. Biosignaling

Jak-Stat Signaling

Biochemistry

12. Biosignaling

Jak-Stat Signaling

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Multiple Choice

How could a cell inhibit the JAK-STAT signal transduction pathway?

Dephosphorylating cytokine receptor tails using phosphatases.

Dephosphorylating STAT dimers using phosphatases.

Using proteins that bind STAT dimers to inhibit their DNA binding.

All of the above are ways to inhibit the JAK-STAT signaling pathway.

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Verified step by step guidance

Understand the JAK-STAT pathway: The JAK-STAT pathway is a chain of interactions between proteins in a cell, and it is used to transmit signals from chemical signals outside of a cell to the cell nucleus, resulting in DNA transcription.

Identify the role of phosphorylation: In the JAK-STAT pathway, phosphorylation is a key step where JAKs (Janus kinases) phosphorylate the receptor and STAT (Signal Transducer and Activator of Transcription) proteins, which then dimerize and translocate to the nucleus to affect gene expression.

Consider dephosphorylation of cytokine receptor tails: Phosphatases can remove phosphate groups from the cytokine receptor tails, preventing the activation of JAKs and subsequent phosphorylation of STAT proteins, thus inhibiting the pathway.

Consider dephosphorylation of STAT dimers: Phosphatases can also target STAT dimers directly, removing phosphate groups and preventing them from translocating to the nucleus and binding to DNA, thereby inhibiting the pathway.

Consider inhibition of DNA binding: Proteins that bind to STAT dimers can prevent them from binding to DNA, even if they are phosphorylated, thus inhibiting the transcriptional activity of the JAK-STAT pathway.