Multiple Choice
Covalent modification of an enzyme usually involves phosphorylation / dephosphorylation of:
7. Enzyme Inhibition and Regulation
Phosphorylation
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During kinase phosphorylation, which phosphate group is removed from ATP in the figure below?
A
α
B
β
C
γ
D
α and β
E
β and γ
Verified step by step guidance1
Identify the structure of ATP in the image, which consists of three phosphate groups labeled as α, β, and γ, attached to an adenosine molecule.
Understand that during kinase phosphorylation, a phosphate group is transferred from ATP to a substrate molecule.
Recognize that the γ-phosphate group is the terminal phosphate group in ATP, which is typically the one removed during phosphorylation reactions.
Recall that the removal of the γ-phosphate group from ATP results in the formation of ADP (adenosine diphosphate), which retains the α and β phosphate groups.
Conclude that the γ-phosphate group is the one removed during kinase phosphorylation, as it is the most distal phosphate group and is involved in the transfer to the substrate.
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