Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Ubiquitination

Biochemistry

7. Enzyme Inhibition and Regulation

Ubiquitination

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Multiple Choice

Ligation of a ubiquitin peptide's ________ charged carboxylate group to the R-group of a target protein's _ residue forms a(n) _________ bond.

Neutrally ; Histidine ; Hydrogen.

Negatively ; Leucine ; Isopeptide.

Positively ; Lysine ; Ionic.

Positively ; Lysine ; Disulfide.

Negatively; Lysine ; Hydrogen.

Negatively ; Lysine ; Isopeptide.

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Verified step by step guidance

Understand the process of ubiquitination: Ubiquitination involves attaching a ubiquitin molecule to a substrate protein, which is crucial for protein degradation and regulation.

Identify the chemical groups involved: The ubiquitin peptide has a carboxylate group, which is negatively charged. This is important for forming a bond with the target protein.

Determine the target residue: The target protein's residue that participates in ubiquitination is typically a lysine. Lysine has an amino group in its side chain, which can form a bond with the carboxylate group.

Recognize the type of bond formed: The bond formed between the carboxylate group of ubiquitin and the amino group of lysine is an isopeptide bond. This is a type of covalent bond that is crucial for the stability of the ubiquitin-protein complex.

Review the options: Match the characteristics of the ubiquitination process with the given options. The correct choice is 'Negatively ; Lysine ; Isopeptide', as it accurately describes the charge of the carboxylate group, the target residue, and the type of bond formed.