Which option best corresponds with the effect of CO 2 on hemoglobin's O 2 -binding?

This practice problem asks, which option best corresponds with the effect of c 02 on hemoglobin's oxygen binding? And we've got these 5 potential answer options below. And so what we need to recall from our previous lesson videos is that c 02 is going to act as a heterotrophic allosteric inhibitor to Hemoglobin's oxygen binding, which means that c 0 2 is going to decrease hemoglobin's oxygen binding. And so keeping that in mind, if we look at option a here, it says that hemoglobins oxygen affinity decreases with lower c o two concentration. But, of course, we know that's not true. The lower the c o two, the less of an inhibitor there is. And that means the lower the c02, the higher hemoglobins oxygen affinity should be and so it shouldn't be decreasing with low c02. So we can go ahead and eliminate option a. Now option b says, Hemoglobin's oxygen affinity increases with higher CO2 concentration. But, of course, higher c02 means we have more of an inhibitor and more of an inhibitor would mean that hemoglobin's oxygen affinity should decrease not increase. So again, we can eliminate option b. Now, option c says, low partial pressure of c02 stabilizes the t state confirmation of Hemoglobin. But, of course, low partial pressure of c 02 means we have a low concentration of inhibitor And that means that it's not going to stabilize the t state. It's actually just going to allow Hemoglobin to, be present in its r state. So, for that reason, we can eliminate option c. So, now, we're between either option d or option e and they're both suggesting, that high p c o two, is going to have, some kind of effect on Hemoglobin. Option d says that it's going to stabilize the r state and option e says it's going to stabilize the t state. And so, of course, having high p c o two means we're gonna have high concentration of inhibitor. And having a high concentration of inhibitor means it's going to stabilize the t state, the tense state. And so, we can go ahead and eliminate option d and indicate option e here is the correct answer. So, that concludes this practice and I'll see you guys in our next video.

Which option best corresponds with the effect of CO 2 on hemoglobin's O 2 -binding?

Hb's O 2 -affinity decreases with lower CO 2 concentration.

Hb's O 2 -affinity increases with higher CO 2 concentration.

High pCO 2 stabilizes the R state conformation of Hemoglobin.

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8. Protein Function

Hemoglobin Carbonation & Protonation

Biochemistry

8. Protein Function

Hemoglobin Carbonation & Protonation

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Multiple Choice

Which option best corresponds with the effect of CO₂ on hemoglobin's O₂-binding?

Hb's O₂-affinity decreases with lower CO₂ concentration.

Hb's O₂-affinity increases with higher CO₂ concentration.

Low pCO₂ stabilizes the T state conformation of Hemoglobin.

High pCO₂ stabilizes the R state conformation of Hemoglobin.

High pCO₂ stabilizes the T state conformation of Hemoglobin.

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Verified step by step guidance

Understand the Bohr effect: The Bohr effect describes how CO2 and H+ ions affect hemoglobin's affinity for oxygen. Increased CO2 levels lead to a decrease in pH, which stabilizes the T state (tense state) of hemoglobin, reducing its affinity for O2.

Identify the T and R states of hemoglobin: Hemoglobin exists in two main conformations, the T state (tense) and the R state (relaxed). The T state has a lower affinity for oxygen, while the R state has a higher affinity.

Consider the impact of CO2 concentration: High levels of CO2 result in increased production of H+ ions, leading to a lower pH. This environment favors the T state, reducing hemoglobin's affinity for oxygen.

Evaluate the options given: The correct option should reflect the relationship between CO2 concentration and hemoglobin's conformation. High pCO2 stabilizes the T state conformation, which corresponds to decreased O2 affinity.

Conclude with the correct answer: Based on the Bohr effect and the stabilization of the T state by high CO2 levels, the correct answer is that high pCO2 stabilizes the T state conformation of hemoglobin.