Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

8. Protein Function

Hemoglobin Carbonation & Protonation

Biochemistry

8. Protein Function

Hemoglobin Carbonation & Protonation

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Multiple Choice

Which statement is true about protons binding to hemoglobin?

Protons stabilize the T-state increasing the affinity of hemoglobin for oxygen.

Protons stabilize the T-state decreasing the affinity of hemoglobin for oxygen.

Protons stabilize the R-state increasing the affinity of hemoglobin for oxygen.

Protons stabilize the R-state decreasing the affinity of hemoglobin for oxygen.

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Verified step by step guidance

Understand the structure of hemoglobin: Hemoglobin is a protein in red blood cells that carries oxygen. It can exist in two states: the T-state (tense) and the R-state (relaxed). The T-state has a lower affinity for oxygen, while the R-state has a higher affinity.

Learn about the Bohr effect: The Bohr effect describes how pH and carbon dioxide concentration affect hemoglobin's oxygen-binding affinity. An increase in protons (H+) or CO2 leads to a decrease in pH, which stabilizes the T-state of hemoglobin.

Analyze the role of protons: Protons bind to specific amino acid residues in hemoglobin, stabilizing the T-state. This stabilization decreases hemoglobin's affinity for oxygen, facilitating oxygen release in tissues where it is needed.

Evaluate the given statements: The correct statement should reflect the effect of protons on hemoglobin's state and oxygen affinity. Protons stabilize the T-state, which decreases the affinity of hemoglobin for oxygen.

Conclude with the correct statement: Based on the understanding of the Bohr effect and hemoglobin's states, the true statement is that protons stabilize the T-state, decreasing the affinity of hemoglobin for oxygen.