Multiple Choice
A suicide inhibitor of an enzyme is one that:
7. Enzyme Inhibition and Regulation
Irreversible Inhibition
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Which of the following statements about irreversible inhibitors is correct?
A
Irreversible inhibitors can only bind to an enzyme active site.
B
Dilution of the inhibited enzyme restores activity.
C
Irreversible inhibitors do not have to bind to the active site.
D
Increasing [S] restores activity to inhibited enzyme.
E
Initially, irreversible inhibitors will reversibly bind.
Verified step by step guidance1
Understand the concept of irreversible inhibitors: These are molecules that bind to an enzyme and permanently inactivate it, often through covalent bonding.
Consider the statement 'Irreversible inhibitors can only bind to an enzyme active site': This is incorrect because irreversible inhibitors can bind to other parts of the enzyme, not just the active site.
Evaluate the statement 'Dilution of the inhibited enzyme restores activity': This is incorrect because once an enzyme is irreversibly inhibited, its activity cannot be restored by dilution.
Analyze the statement 'Increasing [S] restores activity to inhibited enzyme': This is incorrect because increasing substrate concentration does not affect the activity of an enzyme that is irreversibly inhibited.
Review the statement 'Initially, irreversible inhibitors will reversibly bind': This is incorrect as irreversible inhibitors typically form a permanent bond with the enzyme, not a reversible one.
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