Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Irreversible Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Irreversible Inhibition

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Multiple Choice

A suicide inhibitor of an enzyme is one that:

Is reversible.

Is activated by one type of enzyme for the purpose of inhibiting a second type of enzyme.

Is competitive with the enzyme and inactivates the substrate.

Is competitive with the substrate and inactivates the enzyme.

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Verified step by step guidance

Understand the concept of a suicide inhibitor: A suicide inhibitor, also known as a mechanism-based inhibitor, is a type of irreversible enzyme inhibitor that binds to the enzyme as a substrate and is initially processed by the normal catalytic mechanism.

Recognize the irreversible nature: Unlike reversible inhibitors, suicide inhibitors form a covalent bond with the enzyme, leading to permanent inactivation.

Identify the competitive aspect: Suicide inhibitors often compete with the natural substrate for the active site of the enzyme, but once bound, they undergo a transformation that inactivates the enzyme.

Clarify the inactivation process: The inhibitor is converted into a reactive form by the enzyme itself, which then covalently modifies and inactivates the enzyme, preventing further catalytic activity.

Differentiate from other inhibitors: Unlike reversible inhibitors that can dissociate from the enzyme, suicide inhibitors permanently inactivate the enzyme, making them distinct from competitive inhibitors that do not alter the enzyme's structure permanently.