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Multiple Choice
Which of the following amino acids does not have a basic R-group?
A
H
B
S
C
R
D
K
Verified step by step guidance
1
First, understand what is meant by a 'basic R-group' in the context of amino acids. A basic R-group is one that can accept protons (H+) and typically has a positive charge at physiological pH. Common examples include amino acids with side chains containing amine groups.
Next, identify the amino acids represented by the single-letter codes given in the problem: H, S, R, and K. These correspond to Histidine (H), Serine (S), Arginine (R), and Lysine (K), respectively.
Examine the side chains (R-groups) of each of these amino acids: Histidine has an imidazole group, Arginine has a guanidinium group, and Lysine has an amino group. All of these groups can accept protons, making them basic.
Consider the side chain of Serine. Serine has a hydroxyl group (-OH) in its side chain, which is neutral and does not accept protons, thus it is not basic.
Conclude that among the given amino acids, Serine (S) is the one that does not have a basic R-group, as its side chain is neutral and does not participate in proton acceptance.