Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

12. Biosignaling

Inhibitory Adenylate Cyclase GPCR Signaling

Biochemistry

12. Biosignaling

Inhibitory Adenylate Cyclase GPCR Signaling

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Multiple Choice

Which of the following statements about beta-arrestin and GPCRs is TRUE?

Beta-arrestin phosphorylates activated GPCRs.

Beta-arrestin can cause desensitization of a signal by inducing GPCR exocytosis.

Beta-arrestin is pre-bound to inactive GPCRs (no ligand bound).

Beta-arrestin binds to phosphorylated residues on the carboxy-terminus region of GPCRs.

Beta-arrestin binds to phosphorylated residues on the amino-terminus region of GPCRs.

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Verified step by step guidance

Understand the role of GPCRs (G-protein-coupled receptors) in cell signaling. GPCRs are a large family of receptors that respond to various extracellular signals and activate intracellular pathways.

Learn about the function of beta-arrestin in GPCR signaling. Beta-arrestin is a protein that regulates GPCR activity by binding to phosphorylated receptors, which can lead to receptor desensitization and internalization.

Identify the process of GPCR phosphorylation. When a GPCR is activated by a ligand, it undergoes phosphorylation at specific sites, usually on the carboxy-terminus region, which is crucial for beta-arrestin binding.

Clarify the mechanism of beta-arrestin binding. Beta-arrestin binds to phosphorylated residues on the carboxy-terminus region of GPCRs, not the amino-terminus, which is important for receptor regulation.

Evaluate the statements given in the problem. The correct statement is that beta-arrestin binds to phosphorylated residues on the carboxy-terminus region of GPCRs, which is consistent with the known mechanism of beta-arrestin action.