Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

12. Biosignaling

Inhibitory Adenylate Cyclase GPCR Signaling

Biochemistry

12. Biosignaling

Inhibitory Adenylate Cyclase GPCR Signaling

Previous problemNext problem

Struggling with Biochemistry?

Join thousands of students who trust us to help them ace their exams!Watch the first video

Multiple Choice

If a chemical is an inhibitor of the enzyme adenylyl cyclase, which of the following steps in the GPCR signaling pathway would be directly blocked?

Activation of gene transcription.

Exchange of GTP for GDP.

Ligand bound receptor activation.

Synthesis of the secondary messenger cAMP.

Previous problemNext problem

Verified step by step guidance

Understand the role of adenylyl cyclase in the GPCR signaling pathway. Adenylyl cyclase is an enzyme that converts ATP to cyclic AMP (cAMP), which acts as a secondary messenger in the pathway.

Identify the step in the GPCR signaling pathway where adenylyl cyclase is involved. After the ligand binds to the GPCR, the receptor activates a G protein by facilitating the exchange of GDP for GTP on the G protein's alpha subunit.

Recognize that the activated G protein (specifically the Gα subunit) then interacts with adenylyl cyclase, stimulating it to convert ATP into cAMP.

Determine the consequence of inhibiting adenylyl cyclase. If adenylyl cyclase is inhibited, it cannot convert ATP to cAMP, thus blocking the production of the secondary messenger cAMP.

Conclude that the direct step blocked by an inhibitor of adenylyl cyclase is the synthesis of the secondary messenger cAMP, as this is the specific function of adenylyl cyclase in the signaling pathway.