Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

12. Biosignaling

Receptor Tyrosine Kinases

Biochemistry

12. Biosignaling

Receptor Tyrosine Kinases

Previous problemNext problem

Struggling with Biochemistry?

Join thousands of students who trust us to help them ace their exams!Watch the first video

Multiple Choice

Which of the following statements is NOT true of receptor tyrosine kinases?

Monomeric receptors are often induced to dimerize upon ligand binding.

The activated receptors attract and activate G proteins to continue the GPCR signaling pathway.

The cytoplasmic side of RTKs contains a kinase enzyme domain that is partially activated upon ligand binding.

Activated RTKs autophosphorylate themselves and can attract proteins with SH2 domains.

Previous problemNext problem

Verified step by step guidance

Understand the role of receptor tyrosine kinases (RTKs) in cell signaling. RTKs are a type of cell surface receptor that, upon binding with a ligand, undergoes a conformational change leading to activation.

Recognize that RTKs are typically monomeric in their inactive form and often dimerize upon ligand binding. This dimerization is crucial for their activation.

Learn that the cytoplasmic side of RTKs contains a kinase domain. This domain is responsible for transferring phosphate groups from ATP to tyrosine residues on the receptor itself or other proteins, a process known as autophosphorylation.

Understand that activated RTKs can attract proteins with SH2 domains. SH2 domains are specific protein domains that bind to phosphorylated tyrosine residues, facilitating downstream signaling pathways.

Clarify the distinction between RTKs and GPCRs (G protein-coupled receptors). RTKs do not directly attract and activate G proteins; this is a characteristic of GPCRs. Therefore, the statement about RTKs attracting and activating G proteins is incorrect.