Multiple Choice
The catalytic mechanism below is an example of:
6. Enzymes and Enzyme Kinetics
Catalysis
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Which of the following best applies to general acid-base catalysis?
A
A proton is transferred between the enzyme and substrate.
B
Uses nucleophilic functional groups.
C
May take part in interactions involving Fe2+.
D
Catalyst retains its original form after reaction occurs.
E
Other than losing/gaining a H+, the catalyst retains its original form.
F
a & d.
G
a & e.
Verified step by step guidance1
Understand the concept of general acid-base catalysis: It involves the transfer of protons (H+) between the enzyme and the substrate, which can stabilize charged intermediates and facilitate the reaction.
Identify the key characteristics of general acid-base catalysis: The catalyst, often an amino acid side chain in the enzyme, donates or accepts a proton during the reaction.
Recognize that in general acid-base catalysis, the catalyst should retain its original form after the reaction, except for the temporary gain or loss of a proton.
Evaluate the given options: Option 'a' states that a proton is transferred between the enzyme and substrate, which aligns with the definition of general acid-base catalysis.
Option 'e' states that other than losing/gaining a H+, the catalyst retains its original form, which is also a characteristic of general acid-base catalysis. Therefore, the correct answer is a & e.
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