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Multiple Choice
Which of the following could not clearly be a contributor to general acid-base catalysis (circle all that apply)?
A
Lysine.
B
Glutamic acid.
C
Water.
D
Tyrosine.
E
Phenylalanine.
Verified step by step guidance
1
Understand the concept of general acid-base catalysis: In biochemistry, general acid-base catalysis involves the donation or acceptance of a proton (H+) by an acid or base to stabilize the transition state of a reaction, thereby lowering the activation energy and increasing the reaction rate.
Identify the functional groups involved in acid-base catalysis: Amino acids with side chains that can donate or accept protons are typically involved in acid-base catalysis. These include amino acids with carboxyl, amino, or hydroxyl groups.
Evaluate each amino acid option: Consider the side chain properties of each amino acid listed. Lysine has an amino group, Glutamic acid has a carboxyl group, and Tyrosine has a hydroxyl group, all of which can participate in proton transfer.
Consider the role of water: Water can act as both an acid and a base, making it a potential contributor to acid-base catalysis through its ability to donate or accept protons.
Analyze Phenylalanine: Phenylalanine has a non-polar, aromatic side chain that lacks functional groups capable of donating or accepting protons, making it unlikely to participate in general acid-base catalysis.