Which of the following is true about allosteric enzyme conformational states?

An allosteric enzyme that follows the concerted model mechanism has a L ₀ = 10,000 in the absence of substrate. A mutation in this enzyme caused the L₀ to now be 1/10,000 (reciprocal to its original value). What affect does this mutation have on the reaction rate of the enzymatic reaction?

An allosteric enzyme that follows the concerted model mechanism has a L ₀ = 10,000 in the absence of substrate. A mutation in this enzyme caused the L₀ to now be 1/10,000 (reciprocal to its original value). What affect does this mutation have on the reaction rate of the enzymatic reaction?