Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Noncompetitive Inhibition

Biochemistry

7. Enzyme Inhibition and Regulation

Noncompetitive Inhibition

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Multiple Choice

What can be determined from the following Lineweaver Burk plot?

Data collected in the absence (solid line) & presence (dashed line) of a competitive inhibitor.

Data collected in the absence (solid line) & presence (dashed line) of a noncompetitive inhibitor.

Data collected in the absence (dashed line) & presence (solid line) of a competitive inhibitor.

Data collected in the absence (dashed line) & presence (solid line) of a noncompetitive inhibitor.

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Verified step by step guidance

Understand that a Lineweaver-Burk plot is a double reciprocal plot of enzyme kinetics, where 1/[V] (reaction velocity) is plotted against 1/[S] (substrate concentration).

Identify the lines on the plot: the solid line represents data collected in the absence of an inhibitor, and the dashed line represents data collected in the presence of an inhibitor.

Recognize that in a Lineweaver-Burk plot, a competitive inhibitor increases the slope of the line (Km/Vmax) without affecting the y-intercept (1/Vmax), while a noncompetitive inhibitor increases the y-intercept (1/Vmax) without affecting the x-intercept (-1/Km).

Observe the plot: the dashed line (inhibitor present) intersects the y-axis at the same point as the solid line (no inhibitor), indicating that Vmax is unchanged, which is characteristic of competitive inhibition.

Conclude that the data collected in the absence of the inhibitor is represented by the solid line, and the data collected in the presence of a competitive inhibitor is represented by the dashed line.