Multiple Choice
Considering that O2 triggers hemoglobin to switch from its low affinity (T) state to its high affinity (R) state to bind more O2, what kind of allosteric effector is O 2 relative to hemoglobin?
7. Enzyme Inhibition and Regulation
Allosteric Effectors
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Join thousands of students who trust us to help them ace their exams!Watch the first videoMultiple Choice
L-arginine is capable of binding to and activating N-acetylglutamate synthase. Since L-arginine is neither a substrate nor a product of this enzyme, how would this effector be classified?
A
(-) homotropic effector.
B
(+) heterotropic effector.
C
(-) heterotropic effector.
D
(+) homotropic effector.
Verified step by step guidance1
Understand the role of effectors in enzyme activity: Effectors are molecules that bind to an enzyme and influence its activity. They can be classified as either activators or inhibitors.
Differentiate between homotropic and heterotropic effectors: Homotropic effectors are molecules that are also substrates of the enzyme, while heterotropic effectors are not substrates but still influence enzyme activity.
Identify the relationship between L-arginine and N-acetylglutamate synthase: L-arginine binds to and activates N-acetylglutamate synthase, but it is neither a substrate nor a product of this enzyme.
Classify L-arginine based on its interaction with the enzyme: Since L-arginine is not a substrate of N-acetylglutamate synthase, it cannot be a homotropic effector.
Conclude the classification: L-arginine is a heterotropic effector because it is not a substrate of the enzyme but still activates it.
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