Multiple Choice
What side of a membrane has a higher concentration of the toxin Limbricide after ABC transporter activity?
11. Biological Membranes and Transport
ABC Transporters
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Which of the following statements is TRUE for BOTH P-type ATPases and ABC transporters?
A
They each have two ATP-binding protein domains.
B
They both contain a phosphorylated Asp residue.
C
They both are examples of multi-drug resistant proteins that pump toxins out of the cell.
D
They are both dependent on the presence of ATP.
E
They both require ATP binding before substrate binding and transport.
Verified step by step guidance1
Understand the role of ATP in P-type ATPases and ABC transporters. Both types of transporters use ATP to drive the transport of substances across cell membranes.
Recognize that P-type ATPases undergo phosphorylation of an aspartate residue during their transport cycle, which is not a feature of ABC transporters.
Identify that ABC transporters have two ATP-binding domains, which is a characteristic feature, but P-type ATPases do not necessarily have two ATP-binding domains.
Consider the function of these transporters in cellular processes. While some ABC transporters are involved in multi-drug resistance, this is not a universal feature of all P-type ATPases.
Conclude that the common feature between P-type ATPases and ABC transporters is their dependence on ATP, as both require ATP binding to function, making the statement 'They are both dependent on the presence of ATP' true for both.
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