Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

4. Protein Structure

Protein Folding

Biochemistry

4. Protein Structure

Protein Folding

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Multiple Choice

Which of the following is the greatest contributor to spontaneous protein folding?

Decreased chain conformational entropy.

Increased chain conformational entropy.

Decreased entropy of the solvent due to folding.

Increased entropy of the solvent due to folding.

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Verified step by step guidance

Understand the concept of entropy in the context of protein folding. Entropy is a measure of disorder or randomness in a system. In biochemistry, protein folding is influenced by changes in entropy both within the protein chain and the surrounding solvent.

Consider the role of chain conformational entropy. When a protein folds, its chain conformational entropy typically decreases because the protein adopts a more ordered structure. This decrease in entropy is generally unfavorable for spontaneous folding.

Examine the entropy of the solvent. As a protein folds, it often exposes hydrophobic residues that were previously buried. This exposure can lead to an increase in the entropy of the solvent, as water molecules become less ordered around these hydrophobic regions.

Recognize that increased entropy of the solvent is a key driving force for spontaneous protein folding. The disordering of water molecules around hydrophobic residues contributes positively to the overall entropy change, making the folding process more favorable.

Conclude that the greatest contributor to spontaneous protein folding is the increased entropy of the solvent due to folding, as it offsets the decrease in chain conformational entropy and drives the folding process forward.