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Multiple Choice
Which of the following statements regarding integrins is FALSE?
A
Integrins have quaternary protein structure.
B
Integrins are transmembrane protein but most of their functional parts are extracellular.
C
Integrins form tight junctions between cells.
D
The same integrins can have different affinities to ligands depending upon its conformation.
Verified step by step guidance
1
Understand the structure of integrins: Integrins are transmembrane proteins composed of alpha and beta subunits, which means they have a quaternary structure. This is because quaternary structure involves the assembly of multiple polypeptide chains.
Recognize the functional domains of integrins: Integrins span the cell membrane, with parts of the protein extending into the extracellular space to interact with the extracellular matrix and other cells. This means that most of their functional parts are indeed extracellular.
Clarify the role of integrins in cell adhesion: Integrins are involved in cell adhesion, but they do not form tight junctions. Tight junctions are formed by different proteins, such as claudins and occludins, which create a seal between cells.
Explore the concept of integrin-ligand affinity: Integrins can change their conformation, which affects their affinity for ligands. This means that the same integrin can have different binding strengths depending on its conformation.
Identify the false statement: Based on the understanding of integrins' structure and function, the statement that integrins form tight junctions between cells is false, as integrins are not responsible for forming tight junctions.