Multiple Choice
Which of the following reactions does the enzyme adenylate cyclase catalyze?
12. Biosignaling
Stimulatory Adenylate Cyclase GPCR Signaling
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Which of the following molecules is NOT involved in signal transduction of the β-adrenergic GPCR?
A
GTP.
B
ATP.
C
cAMP.
D
cGMP.
E
GDP.
Verified step by step guidance1
Understand the role of β-adrenergic GPCRs: These are G protein-coupled receptors that, when activated by ligands such as adrenaline, initiate a signaling cascade inside the cell.
Identify the key molecules involved in the β-adrenergic GPCR signaling pathway: Typically, this involves the activation of a G protein, which exchanges GDP for GTP, and the production of cAMP from ATP by adenylyl cyclase.
Recognize the role of GTP and GDP: GTP is used to activate the G protein, while GDP is released when the G protein is inactivated.
Understand the role of ATP and cAMP: ATP is converted to cAMP, which acts as a secondary messenger to propagate the signal within the cell.
Identify cGMP: cGMP is a cyclic nucleotide similar to cAMP but is not typically involved in the β-adrenergic GPCR signaling pathway, making it the correct answer as the molecule not involved in this specific pathway.
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