Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

7. Enzyme Inhibition and Regulation

Concerted (MWC) Model

Biochemistry

7. Enzyme Inhibition and Regulation

Concerted (MWC) Model

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Multiple Choice

Which of the following is true concerning the symmetry rule & the Concerted model of allosterism?

The protein is an oligomer of symmetrically related proteins.

Though not with the same affinity, the ligand can bind to a subunit in either conformation.

The oligomer can only exist in one of two conformational states (T & R), which are in equilibrium.

All the above are true.

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Verified step by step guidance

Understand the concept of allosterism: Allosterism refers to the regulation of a protein's activity through the binding of an effector molecule at a site other than the protein's active site. This can result in a change in the protein's conformation and activity.

Familiarize yourself with the Concerted model (also known as the Monod-Wyman-Changeux model): This model suggests that all subunits of an oligomeric protein are in the same conformation, either tense (T) or relaxed (R), and that the transition between these states is concerted, meaning it happens simultaneously for all subunits.

Examine the symmetry rule: In the context of the Concerted model, the symmetry rule states that the protein is an oligomer composed of symmetrically related subunits. This means that all subunits are structurally identical and undergo conformational changes together.

Analyze the statement about ligand binding: According to the Concerted model, a ligand can bind to a subunit in either the T or R conformation, although the affinity may differ between these states. This is consistent with the model's assumption that the entire oligomer shifts between the T and R states.

Consider the equilibrium between conformational states: The Concerted model posits that the oligomer can exist in one of two conformational states (T or R), which are in equilibrium. This means that the protein can switch between these states, influenced by ligand binding and other factors.