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Multiple Choice
At a CO2 partial pressure of 5 torr, the p50 value for hemoglobin is 26 torr. What is the fractional saturation when nH = 3 and pO2 = 25 torr, a typical venous oxygen partial pressure?
A
1.1
B
0.68
C
0.12
D
0.88
E
0.47
Verified step by step guidance
1
Understand the concept of fractional saturation (Y) in the context of hemoglobin, which is the fraction of oxygen-binding sites occupied by oxygen. It can be calculated using the Hill equation.
The Hill equation is given by: , where Y is the fractional saturation, pO2 is the partial pressure of oxygen, p50 is the partial pressure at which hemoglobin is 50% saturated, and n is the Hill coefficient.
Substitute the given values into the Hill equation: .
Calculate the numerator: .
Calculate the denominator: and then divide the numerator by the denominator to find the fractional saturation Y.