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Multiple Choice
Insulin binds to a receptor that: I. Is coupled to a G protein. II. Possesses tyrosine kinase activity. III. Possesses serine/threonine phosphatase activity. IV. Interacts with the adapter protein IRS-1.
A
I, III and V.
B
II and IV.
C
I, II and V.
D
II, IV and V.
E
IV and V.
Verified step by step guidance
1
Understand the role of insulin in the body: Insulin is a hormone that regulates glucose uptake and metabolism. It binds to specific receptors on the cell surface to initiate its effects.
Identify the type of receptor insulin binds to: Insulin binds to the insulin receptor, which is a type of receptor tyrosine kinase. This means it has intrinsic tyrosine kinase activity, allowing it to phosphorylate tyrosine residues on certain proteins.
Evaluate the options based on receptor activity: Since the insulin receptor has tyrosine kinase activity, option II is correct. It does not couple with G proteins, so option I is incorrect.
Consider the role of adapter proteins: The insulin receptor interacts with the adapter protein IRS-1 (Insulin Receptor Substrate 1), which is crucial for downstream signaling. This makes option IV correct.
Review the incorrect options: The receptor does not possess serine/threonine phosphatase activity, so option III is incorrect. Therefore, the correct answer is the combination of options II and IV.