Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

4. Protein Structure

Atypical Ramachandran Plots

Biochemistry

4. Protein Structure

Atypical Ramachandran Plots

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Multiple Choice

Why does Gly have a uniquely interesting Ramachandran plot in comparison to the other α-amino acids?

Its small R-group restricts the φ and ψ bond rotations via noncovalent interactions.

Glycine's R-group forms strong hydrogen bonds that greatly frees its bond rotations.

Gly's R-group avoids steric hindrance & expands regions of energetically permissible φ and ψ bond angles.

b and c.

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Verified step by step guidance

Understand the structure of glycine: Glycine is the simplest amino acid with an R-group that is just a hydrogen atom. This small size is crucial for its unique properties.

Explore the concept of steric hindrance: In most amino acids, larger R-groups can cause steric hindrance, limiting the range of φ (phi) and ψ (psi) angles due to spatial constraints.

Analyze the Ramachandran plot: The Ramachandran plot is a graphical representation of the φ and ψ angles of amino acids in protein structures. It shows the energetically favorable conformations.

Consider glycine's flexibility: Due to its small R-group, glycine experiences minimal steric hindrance, allowing a wider range of φ and ψ angles compared to other amino acids.

Conclude the impact on the Ramachandran plot: Glycine's lack of steric hindrance expands the regions of permissible φ and ψ angles, making its Ramachandran plot uniquely interesting and different from other amino acids.