Identify all the correct statements regarding the Bohr effect on hemoglobin. i) The Bohr effect shifts the fractional O 2 saturation curve to the right as pH decreases. ii) The Bohr effect shifts the fractional O 2 saturation curve to the right as pH increases. iii) The Bohr effect favors O 2 release in respiring tissues. iv) O 2 and H + compete for the same binding site on hemoglobin.

So this practice problem wants us to identify all the correct statements regarding the Bohr effect on hemoglobin, and we've got the 4 statements listed right here. And then down below, we have the answer options, which will help us select exactly which statements are correct. And so looking at the first statement, it says that the Bohr effect shifts the fractional oxygen saturation curve to the right as pH decreases. Now we know already from our previous lesson videos that a pH decrease is associated with our tissues, where the pH is right around 7.2. And so this is because again our tissues are actively producing lactic acid and lots of c o two that increase the concentration of hydrogen ions leading to a pH decrease. And so what we need to recall from our previous lesson video are, the curves of the bore effect. And so notice, in green here, what we have is the curve in our tissues where the pH is decreased and notice that the curve right here in our tissues corresponds with an oxygen saturation curve shift to the right. And so it seems as if statement 1 here is going to be true. And so, we can go ahead and highlight it green. Now moving on to statement 1, it says that the Bohr effect shifts the fractional oxygen saturation curve to the right as pH increases, but, of course, we know this is not going to be true and that's because a pH increase we know is associated with the lungs where the pH is right around 7.6 and that's because of a decrease in the hydrogen ions And so, we can see that the blue curve over here corresponds with the lungs and it's not being shifted to the right, it's being shifted to the left with respect to the red curve. And so moving on, to statement 3 here, it says that the Bohr effect favors oxygen release and respiring tissues. And so, of course, if we take a look at our tissues curve here, we can see that it, the fractional saturation is always going to be lower, with the tissues curve. And a lower saturation means less binding of oxygen and less binding of oxygen means more release, more oxygen release. And so statement 3 is also going to be true, because it associates the green curve. And so, taking a look at our final statement, statement for it says, oxygen and hydrogen ions compete for the same binding site on hemoglobin. Now we know from our previous lesson videos that oxygen is going to bind to the iron atom of the heme group, but the hydrogen ions will actually bind to the r groups of specific amino acids. And so they don't actually compete for the same binding site on hemoglobin and this is a false statement. And so we only wanna select the statements, 13 as being correct. So that matches with answer option a. And so we can indicate that a is the correct answer for this problem, and that concludes this practice. So I'll see you guys in our next the video.

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1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
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8. Protein Function 9h 41m
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Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
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Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

8. Protein Function

Bohr Effect

Biochemistry

8. Protein Function

Bohr Effect

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Multiple Choice

Identify all the correct statements regarding the Bohr effect on hemoglobin.
i) The Bohr effect shifts the fractional O₂ saturation curve to the right as pH decreases.
ii) The Bohr effect shifts the fractional O₂ saturation curve to the right as pH increases.
iii) The Bohr effect favors O₂ release in respiring tissues.
iv) O₂ and H⁺ compete for the same binding site on hemoglobin.

i & iii.

i & iv.

ii & iv.

ii, iii, & iv.

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Verified step by step guidance

Understand the Bohr effect: The Bohr effect describes how changes in pH and carbon dioxide concentration affect the binding and release of oxygen by hemoglobin.

Analyze statement i: The Bohr effect shifts the fractional O2 saturation curve to the right as pH decreases. This is correct because a decrease in pH (more acidic conditions) reduces hemoglobin's affinity for oxygen, facilitating oxygen release.

Analyze statement ii: The Bohr effect shifts the fractional O2 saturation curve to the right as pH increases. This is incorrect because an increase in pH (more basic conditions) actually increases hemoglobin's affinity for oxygen, shifting the curve to the left.

Analyze statement iii: The Bohr effect favors O2 release in respiring tissues. This is correct because respiring tissues produce CO2 and H+, lowering pH and promoting oxygen release from hemoglobin.

Analyze statement iv: O2 and H+ compete for the same binding site on hemoglobin. This is incorrect because H+ ions bind to different sites on hemoglobin, inducing conformational changes that affect oxygen binding indirectly.