Multiple Choice
The Chloride-Shift occurs when:
11. Biological Membranes and Transport
Erythrocyte Facilitated Transporter Models
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Which of the following correctly ranks the steps of erythrocyte glucose transport by GLUT1?
I. A conformational change exposes glucose to the opposite site of the membrane.
II. Glucose binds to the transporter on one side of the membrane.
III. The GLUT1 transporter reverts back to its initial conformation.
IV. The glucose molecule has a weakened affinity to GLUT1 and dissociates from the transporter.
A
II, I, III, IV.
B
II, I, IV, III.
C
IV, III, II, I
D
I, II, IV, III.
E
IV, II, III, I
Verified step by step guidance1
Understand the role of GLUT1: GLUT1 is a glucose transporter that facilitates the passive transport of glucose across the cell membrane.
Identify the initial step: Glucose must first bind to the GLUT1 transporter on one side of the membrane. This is step II.
Recognize the conformational change: Once glucose is bound, GLUT1 undergoes a conformational change to expose glucose to the opposite side of the membrane. This is step I.
Determine the release of glucose: The glucose molecule then has a weakened affinity to GLUT1 and dissociates from the transporter. This is step IV.
Conclude with the reset of the transporter: Finally, the GLUT1 transporter reverts back to its initial conformation, ready to bind another glucose molecule. This is step III.
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