Table of contents

1. Introduction to Biochemistry4h 34m
2. Water3h 23m
3. Amino Acids8h 10m
4. Protein Structure10h 4m
5. Protein Techniques14h 5m
6. Enzymes and Enzyme Kinetics13h 38m
7. Enzyme Inhibition and Regulation 8h 42m
8. Protein Function 9h 41m
9. Carbohydrates7h 49m
10. Lipids5h 49m
11. Biological Membranes and Transport 6h 37m
12. Biosignaling9h 45m
Review 1: Nucleic Acids, Lipids, & Membranes2h 47m
Review 2: Biosignaling, Glycolysis, Gluconeogenesis, & PP-Pathway3h 12m
Review 3: Pyruvate & Fatty Acid Oxidation, Citric Acid Cycle, & Glycogen Metabolism2h 26m
Review 4: Amino Acid Oxidation, Oxidative Phosphorylation, & Photophosphorylation1h 48m

4. Protein Structure

Chaperone Proteins

Biochemistry

4. Protein Structure

Chaperone Proteins

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Multiple Choice

Heat shock protein 70 (HSP70), a chaperone protein found in many organisms, is one of the most highly conserved proteins in all of biology. Which of the following statements about HSP70 is true?

HSP70 operates by forming a large cage around the unfolded polypeptide to increase its solubility.

HSP70 facilitates proper protein folding without the use of energy.

Cellular expression of HSP70 concentration significantly increases in high temperature environments.

Expression of HSP70 concentration decreases or stays constant in high temperature environments.

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Verified step by step guidance

Understand the role of HSP70: Heat shock proteins like HSP70 are molecular chaperones that assist in the proper folding of proteins, especially under stress conditions such as elevated temperatures.

Analyze the statement about HSP70 forming a large cage: This description is more characteristic of chaperonins like GroEL/GroES, not HSP70. HSP70 works by binding to nascent or unfolded polypeptides to prevent aggregation.

Consider the energy requirement: HSP70 requires ATP to function. It binds and releases polypeptides in an ATP-dependent manner, facilitating proper folding.

Evaluate the statement about expression levels: HSP70 expression is upregulated in response to stress conditions, such as high temperatures, to protect cells by ensuring proteins fold correctly.

Conclude with the correct statement: The statement 'Cellular expression of HSP70 concentration significantly increases in high temperature environments' is true, as it aligns with the known function of HSP70 in stress response.