Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?
b. Hydrolysis to free glucose

Question

Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?

b. Hydrolysis to free glucose

Accepted Answer

All right. Hello everyone. So this question says that fructose 16 P phosphate is a key intermediate in metabolism and the glycolysis pathway pathway, which of the following conditions and statements below is correct. So for this question, we have four different answer choices labeled A through D that we're going to go ahead and discuss individually. So let's start with option. A option A says that fructose 16 bisphosphate is converted to pyruvate in the presence of oxygen through the enzyme hexokinase. So this is not quite right, right. This is actually going to be incorrect because focusing for just a second on the name of the enzyme here, hexokinase indicates some information about its function, right? Because when we talk about an enzyme with the suffix kinase, what that essentially means is that it's going to add a phosphate group to something, right? It's going to add a phosphate group two, some intermediate or rather some reagent I should say. And that makes sense if you recall the fact that hexokinase is the enzyme necessary for the first step of the glycolysis pathway. Because hexokinase catalyzes the phosphorylation of glucose to produce glucose six phosphate rather it's phosphoenolpyruvate that's converted into pyruvate with an enzyme known as pyruvate kinase. So option A is incorrect. Now, option B says that fructose 16 bisphosphate converts to pyruvate only under anaerobic conditions without any additional steps. So, option B is another one that we can eliminate because like option A, it's implying the fact that fructose 16 phosphate is converted to pyruvate directly. That's not true for the reasons we discussed when talking about option A, there are multiple steps in between the formation of fructose 16 P phosphate and the formation of pyro at the end of the glycolysis pathway. And not only is that the case but glycolysis as a whole can occur under both aerobic meaning with oxygen and anaerobic conditions. So B is not true for two reasons. Now lets move on to option. C option C says that fructose 16 bisphosphate is converted to pyruvate through glycolysis involving steps like the formation of glyceraldehyde three phosphate. 13 bis phospho glycate and three phospho glycate. This is true, right? Because it's describing multiple intermediates that are formed in between fructose, 16 bisphosphate and eventually pyruvate. Now recall specifically that fructose 16 bisphosphate is cleaved to produce two main products, we have dihydroxyacetone phosphate or DH A P for short alongside glyceraldehyde three phosphate. And after the formation of these two intermediates, dihydroxy acetone phosphate is converted to another equivalent of glyceraldehyde three phosphate. And from there, G three P is converted into pyruvate after multiple steps in between. Now, before we talk about option D, just for the sake of completion, I do want to point out that the intermediates described in option C are actually in the correct order because first, you have the formation of glyceraldehyde three phosphate, which is then phosphorated into 13 bis phospho glycerated, which is then converted to three phospho glycerated. So that's just for your information. This leads us now to option D which says that the conversion of fructose 16 P phosphate to pyruvate occurs directly through the enzyme. Phosphofructokinase one or PFK one. This is not true because once again, it's implying that only one enzyme and therefore only one step is needed to go from fructose 16 phosphate to pyruvate. Once again, that is not true. There are multiple steps in between the formation of these two compounds. Now, specifically phospho fructose fructokinase. One allows for the conversion of fructose six phosphate into fructose, 16, this phosphate. So essentially PFK one adds an additional phosphate group to fructose six phosphate and there you have it. So we've gone through all of our answer choices and the only one that accurately describes the glycolysis pathway is option C and so with that being said, thank you so very much for watching and I hope you found this helpful

Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?
b. Hydrolysis to free glucose

Verified video answer for a similar problem:

Key Concepts

Glucose 6-Phosphate Metabolism

Conditions for Hydrolysis

Hormonal Regulation

Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?b. Hydrolysis to free glucose

Verified video answer for a similar problem:

Key Concepts

Glucose 6-Phosphate Metabolism

Conditions for Hydrolysis

Hormonal Regulation

Glucose 6-phosphate is in a pivotal position in metabolism. Depending on conditions, glucose 6-phosphate follows one of several pathways. Under what conditions do the following occur?
b. Hydrolysis to free glucose